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PDCD4 inhibited ovarian cancer cell migration and invasion.

By Na Wei (122650), Stephanie S. Liu (187817), Karen K. L. Chan (109250) and Hextan Y. S. Ngan (109252)

Abstract

<p>(A) Both control and PDCD4 over-expressing cells were treated with mitomycin C (10 ug/ml) for three hours prior to introduction of the wound. Photos were taken at indicated time points (0, 5, 8 and 23 h). PDCD4 over-expressing stable clones exhibited slower wound healing process compared with the control. (B) Ovarian cancer cells were allowed to migrate through the microporous membrane for 9 hours in transwell migration assay. The numbers of cells migrated through for PDCD4 over-expressing stable clones were significantly fewer compared with control (*p<0.01 and **p<0.05, respectively). (C) Ovarian cancer cells were allowed to invade through the ECMatrix for 72 hours in transwell invasion assay. The numbers of cells invaded through for PDCD4 over-expressing stable clones were significantly fewer compared with control (*p<0.05). Experiments were performed in triplicate.</p

Topics: Molecular Biology, inhibited, ovarian, cancer
Year: 2012
DOI identifier: 10.1371/journal.pone.0030311.g002
OAI identifier: oai:figshare.com:article/362325
Provided by: FigShare
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