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TBC-8 localizes to the Golgi-endosomal interface.

By Mandy Hannemann (162954), Nikhil Sasidharan (162958), Jan Hegermann (162959), Lena M. Kutscher (162965), Sabine Koenig (162972) and Stefan Eimer (162977)


<p>(A) The subcellular localization of fluorescently-labeled TBC-8 expressed in motoneurons was analyzed by confocal microscopy. Fluorescently-labeled-TBC-8 localized partially with medial and trans-Golgi markers and showed full co-localization with the early endosomal marker mCherry-RAB-5. No co-localization to RAB-7-positive late endosomes was observed. (B) In motoneurons, mCherry-RAB-2 localizes to the Golgi (left cell body; cell boundary is highlighted by a dashed line). However, when YFP-TBC-8 is overexpressed, mCherry-RAB-2 is redistributed to the cytosol (right cell body). Manns: mannosidase II, TGN: trans-Golgi network. Scale bars represent 3 µm.</p

Topics: Cell Biology, Neuroscience, localizes, golgi-endosomal
Year: 2012
DOI identifier: 10.1371/journal.pgen.1002722.g005
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Provided by: FigShare
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