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P38MAPK, ERK and PI3K pathway inhibitors block C5a-primed neutrophils for ANCA-induced degranulation.

By Jian Hao (160736), Li-Qiang Meng (160743), Peng-Cheng Xu (160751), Min Chen (147733) and Ming-Hui Zhao (160760)


<p>ANCA-induced neutrophil degranulation was determined by measuring the lactoferrin concentrations in the supernatant of neutrophil degranulation reaction. Inhibition of p38MAPK, ERK and PI3K reduced ANCA-induced lactoferrin release. Bars represent mean±SD of 3 MPO-ANCA and 3 PR3-ANCA preparations, measured on neutrophils of 4 donors. T test was used to compare concentration of lactoferrin between groups.</p

Topics: Cell Biology, Molecular Biology, Immunology, erk, PI3K, pathway, inhibitors, c5a-primed, neutrophils, anca-induced
Year: 2012
DOI identifier: 10.1371/journal.pone.0038317.g004
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Provided by: FigShare
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