<p>ANCA-induced neutrophil degranulation was determined by measuring the lactoferrin concentrations in the supernatant of neutrophil degranulation reaction. Inhibition of p38MAPK, ERK and PI3K reduced ANCA-induced lactoferrin release. Bars represent mean±SD of 3 MPO-ANCA and 3 PR3-ANCA preparations, measured on neutrophils of 4 donors. T test was used to compare concentration of lactoferrin between groups.</p
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