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Induction of IL-10-producing CD4<sup>+</sup> T cells by <i>B. breve</i> in the colonic lamina propria.

By Seong Gyu Jeon (161896), Hisako Kayama (161900), Yoshiyasu Ueda (161908), Takuya Takahashi (161915), Takashi Asahara (161918), Hirokazu Tsuji (161923), Noriko M. Tsuji (161928), Hiroshi Kiyono (69959), Ji Su Ma (161935), Takashi Kusu (161940), Ryu Okumura (161945), Hiromitsu Hara (161948), Hiroki Yoshida (85600), Masahiro Yamamoto (39398), Koji Nomoto (161952) and Kiyoshi Takeda (161954)


<p>6-week-old C57BL/6 mice were fed <i>L. casei</i> or <i>B. breve</i> or placebo daily (each, 1×10<sup>9</sup>) by oral gavage for 3 months (n = 8). Intestinal lamina propria lymphocytes were analyzed for cytokine production by flow cytometry. Percentages of IL-10-, IL-17-, and IFN-γ-producing CD4<sup>+</sup> T cells of mice administered with <i>L. casei</i> (<b>A</b>) or <i>B. breve</i> (<b>C</b>) were shown. *P<0.05. (<b>B</b>, <b>D</b>) Representative FACS dot plots showing production of IL-10 and IFN-γ gated on colonic CD4<sup>+</sup> T cells in the indicated mice.</p

Topics: Chemistry, il-10-producing, cells, colonic, lamina
Year: 2012
DOI identifier: 10.1371/journal.ppat.1002714.g001
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Provided by: FigShare
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