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The Rab cycle.

By Joel R. Ho (157387), Elodie Chapeaublanc (157397), Lisa Kirkwood (157406), Remy Nicolle (157411), Simone Benhamou (111834), Thierry Lebret (111837), Yves Allory (111840), Jennifer Southgate (110308), François Radvanyi (13822) and Bruno Goud (157424)


<p>Rab GTPases cycle between an active GTP-bound form and an inactive GDP-bound form. Rab activation is mediated by a guanine exchange factor (GEF). The hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) resulting in the inactivation of the Rab protein. In its active form, the Rab is associated with membranes and can interact with a variety of effector proteins. In its inactive form the protein is cytosolic and is in complex with a GDP dissociation inhibitor (GDI) protein.</p

Topics: Cell Biology, Genetics, Molecular Biology, Cancer, rab
Year: 2012
DOI identifier: 10.1371/journal.pone.0039469.g003
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Provided by: FigShare
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