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α-Tomatine affected mitochondrial apoptotic or anti-apoptotic protein levels.

By Min-Wu Chao (137769), Chun-Han Chen (137771), Ya-Ling Chang (16726), Che-Ming Teng (137773) and Shiow-Lin Pan (137778)

Abstract

<p>(<b>A</b>) α-Tomatine induced Mcl-1s and Bak up-regulations (pro-apoptotic) but did not affect Bcl-2 and Bid protein levels in the HL60 cells. (<b>B</b>) In the K562 cells, α-tomatine significantly enhanced the activation of Bak and up-regulated Mcl-1s; however α-tomatine did not influence Bcl-2 and Bid protein expressions. Both cell lines were treated with 5 µM α-tomatine for the indicated intervals. Data are expressed from at least three separate determinations.</p

Topics: Cell Biology, Pharmacology, Cancer, Hematology, affected, mitochondrial, apoptotic, anti-apoptotic
Year: 2012
DOI identifier: 10.1371/journal.pone.0044093.g005
OAI identifier: oai:figshare.com:article/251727
Provided by: FigShare
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