Article thumbnail

Effects of <i>asm-3</i> on dauer formation regulation in various mutants defective in the<i>daf-2</i> signaling.

By Yongsoon Kim (132228) and Hong Sun (132232)


<p>(A) Loss of <i>asm-3</i> enhanced dauer formation of <i>daf-2(e1370)</i> mutants at the semi-permissive temperature 22.5°C. (B) <i>asm-3</i> mutation greatly enhanced dauer arrest phenotype of <i>age-1(mg305)</i> mutants at 22.5°C. (C) <i>asm-3</i> mutation did not affect dauer arrest induced by the <i>pdk-1(sa709)</i> mutation at 27°C. The mutant animals carrying <i>sa709</i> allele formed dauer at 27°C but not at 25°C. (D) <i>asm-3</i> mutation partially suppressed the dauer arrest phenotype of <i>akt-1(mg306)</i> mutants at 27°C. No dauers at 25°C were observed for the <i>akt-1(mg306)</i> mutant animals with or without the presence of the <i>asm-3(ok1744)</i> allele. (E) <i>asm-3</i> mutation had no effect on dauer arrest phenotype of <i>daf-7(e1372)</i> mutants at either 22.5°C or 25°C. The <i>asm-3(ok1744)</i> allele by itself did not induce dauer formation at either 22.5°C or 25°C. Error bars indicate standard deviation from triplicates. Details including total worm numbers used in the assay are listed in <a href="" target="_blank">Table S1</a>.</p

Topics: Biochemistry, Genetics, Physiology, dauer, mutants, defective
Year: 2012
DOI identifier: 10.1371/journal.pone.0045890.g003
OAI identifier:
Provided by: FigShare
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.