<p>A) ‘Reverse model’ <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003134#pgen.1003134-Shimada1" target="_blank">[13]</a>, B) ‘Original model’ <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003134#pgen.1003134-Distelfeld2" target="_blank">[12]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003134#pgen.1003134-Trevaskis3" target="_blank">[37]</a>.Green arrows indicate promotion of transcription and red lines repression of transcription.</p
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