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High dose zinc supplementation induces hippocampus-dependent memory impairment.

By Yang Yang (45629), Xiao-Peng Jing (285881), Shou-Peng Zhang (285883), Run-Xia Gu (285887), Fang-Xu Tang (285889), Xiu-Lian Wang (285892), Yan Xiong (197517), Mei Qiu (285895), Xu-Ying Sun (285898), Dan Ke (285899), Jian-Zhi Wang (285900) and Rong Liu (202610)


<p>(A) T-maze task for working memory assessment of zinc supplemented mice (n = 8). Compared with control mice, high-dose zinc supplemented mice exhibited working memory deficit. (B–C) Contextual discrimination test of the mice (n = 16).High-dose zinc supplemented mice showed significantly lower discrimination ratio than the other two groups across the seven days of acquisition. Low-dose zinc supplemented mice showed better discrimination than control in the last three testing days (B). Seven days later, the discrimination was recorded again, control and low-dose zinc supplemented mice could discriminate the two contexts whereas high-dose zinc supplemented mice still could not (C). (D) Contextual fear conditioning test of the mice (n = 16). There was no difference in freezing ratio among the three groups. (E–F) Open field test of the mice (n = 16). There was no difference in locomotor habituation among the three groups (E); Low-dose zinc supplemented mice showed shorter time in the center square than control, indicating increased anxiety in this group. *, <i>p</i><0.05; **, <i>p</i><0.01;***, <i>p</i><0.001 vs. control group.</p

Topics: Neuroscience, zinc, supplementation, induces, hippocampus-dependent
Year: 2013
DOI identifier: 10.1371/journal.pone.0055384.g001
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Provided by: FigShare
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