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Effects of the AA/PGE<sub>2</sub> pathway on the ELF-EMF exposure-induced increase in <i>I</i><sub>Na</sub> in cerebellar GCs.

By Yan-Lin He (287977), Dong-Dong Liu (287979), Yan-Jia Fang (287981), Xiao-Qin Zhan (287984), Jin-Jing Yao (287987) and Yan-Ai Mei (287989)

Abstract

<p>(A) PGE<sub>2</sub> release from cerebellar GCs exposed to 1 mT ELF-EMF for various lengths of time. The data are from three and four independent experiments, respectively. *, <i>P</i>< 0.05 compared to the corresponding control using Student’s <i>t</i>-test. (B) Intracellular AA levels in cerebellar GCs exposed to 1 mT ELF-EMF for various lengths of time. The data are from three and four independent experiments, respectively. *, <i>P</i>< 0.05 compared to the corresponding control using Student’s <i>t</i>-test. (C) Current traces show the inhibitory effects of the COX-2 inhibitors flufenamaic acid (FA) and niflumic acid (NA) on the increase in <i>I</i><sub>Na</sub> induced by 60 minutes of exposure to a 1 mT ELF-EMF. (D) Statistical analysis of the effects of FA and NA on the increase in <i>I</i><sub>Na</sub> induced by a 60-minute exposure to a 1 mT ELF-EMF. (E) Statistical analysis of the effects of FA and NA on PGE<sub>2</sub> release induced by a 60-minute exposure to a 1 mT ELF-EMF.</p

Topics: Physics, Neuroscience, pathway, elf-emf, exposure-induced, cerebellar
Year: 2013
DOI identifier: 10.1371/journal.pone.0054376.g006
OAI identifier: oai:figshare.com:article/176009
Provided by: FigShare
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