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Postprandial triglyceridemia, gut hormones, and gastric emptying in <i>Dgat1</i>+/− and <i>Dgat1</i>−/− mice.

By Hua V. Lin (185423), Dunlu Chen (288481), Zhu Shen (288482), Lei Zhu (16642), Xuesong Ouyang (268802), Aurawan Vongs (288483), Yanqing Kan (288485), John M. Levorse (288486), Edward J. Kowalik Jr (288488), Daphne M. Szeto (288490), Xiaorui Yao (288491), Jianying Xiao (288492), Shirley Chen (288493), Jinqi Liu (288494), Marga Garcia-Calvo (288495), Myung K. Shin (288496) and Shirly Pinto (288497)

Abstract

<p>4- to 5-month-old <i>Dgat1</i>+/−, <i>Dgat1</i>−/−, and wild type mice maintained on normal chow diet were fasted overnight, then p.o. dosed with (A–F) corn oil (100% lipid load, 8.14 kcal/ml) or (G–L) a mixed meal containing corn oil:Ensure-plus = 3∶17 v/v (19.4% lipid load, 2.48 kcal/ml) at 10 ml/kg body weight. At 2 h after meal challenge, plasma levels of (A) TG, (B, H) active GLP-1, (C, I) total GLP-1, (D, J) PYY, (E, K) GIP, and (F, L) stomach weight were measured. (G) In a separate cohort, plasma TG at 0, 1, 2, and 4h after 19.4% lipid load was determined. N = 8–12. *P<0.05, **P<0.01, ***P<0.001 vs. wild type. <sup>#</sup>P<0.05, <sup>##</sup>P<0.01, <sup>###</sup>P<0.001 <i>Dgat1</i>−/− vs. <i>Dgat1</i>+/−.</p

Topics: Biochemistry, Genetics, gastric, emptying
Year: 2013
DOI identifier: 10.1371/journal.pone.0054480.g002
OAI identifier: oai:figshare.com:article/177341
Provided by: FigShare
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