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Fibrosis following ischemia-reperfusion in treated rats.

By Apoorva S. Salimath (296376), Edward A. Phelps (296378), Archana V. Boopathy (296380), Pao-lin Che (296382), Milton Brown (296384), Andrés J. García (2488963) and Michael E. Davis (296387)


<p>At 21 days following infarction, fibrosis was measured by staining for collagen using picrosirius red (red stain, images taken at 20× magnification). A) Shows 2 representative stitched heart sections used for quantification (IR alone and IR + PEG/VEGF/HGF. B) Grouped data (mean ± SEM; n≥7 per group) demonstrating a significant decrease in fibrotic area in PEG/HGF/VEGF rats compared with IR alone (*p<0.05; ANOVA followed by Student-Newman-Keuls post-test). PEG = polyethyleneglycol, VEGF = vascular endothelial growth factor, HGF = hepatocyte growth factor, IR = ischemia reperfusion, LV = left ventricle.</p

Topics: Biotechnology, ischemia-reperfusion, treated
Year: 2013
DOI identifier: 10.1371/journal.pone.0050980.g003
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Provided by: FigShare
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