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Macroscopic and microscopic structure of the uterus at 48 h after treatment with different dosages of RU 486.

By Fang Lv (300995), Xiangbo Xu (300996), Shucheng Zhang (300997), Lili Wang (104605), Ning Wang (108353), Bin He (75597) and Jiedong Wang (300998)


<p>On day 8.5 of pregnancy, mice were treated with 3 different doses (0.3, 2, or 20 mg/kg) of RU 486. Uterine tissues were examined 48 h after the treatment. (A) Treatment with 0.3 mg/kg RU 486 caused termination of pregnancy in 60% of mice (3/5). The weight of the uterus increased, and the abortion was incomplete. (B) Treatment with 2 mg/kg RU 486 caused termination of pregnancy in 100% of cases, and the aborted horn completely regenerated. (C) Treatment with 20 mg/kg RU 486 caused pregnancy loss in 100% of mice and led to uterine dropsy (fluid retention: 3/5 mice [60%]). Therefore, the 2 mg/kg dosage was considered optimal for inducing abortion.</p

Topics: Cell Biology, Molecular Biology, Biological Sciences, microscopic, uterus, 48, dosages, ru
Year: 2013
DOI identifier: 10.1371/journal.pone.0048384.g002
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Provided by: FigShare
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