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Specification and differentiation of the ocular adnexa at E15.5.

By Dennis S. Rice (304216), Gwenn M. Hansen (304218), Feng Liu (72874), Mike J. Crist (304223), Matthew M. Newhouse (304224), David Potter (304225), Nianhua Xu (133512), Alejandro Abuin (304229), Peter J. Vogel (304230) and Brian P. Zambrowicz (304232)


<p>Cryosections were stained with various markers of keratinocyte differentiation. For orientation purposes c  =  cornea and r  =  retina in all images. Keratin 10 (K10) is expressed in papebral epidermis (ep) in wild type (A, +/+) and LIMK2-deficient (B, −/−) eyelids. The conjunctiva (conj.) is negative for K10 expression. An antibody recognizing phosphorylated c-Jun labels nuclei in cells (arrows) at the tip of the eyelid in both +/+ (C) and −/− (D) mice. Keratin 6 (K6) is expressed in epithelial cells at the tip of the eyelids in both +/+ (E) and −/− (F) mice, consistent with induction of a migratory phenotype. Scale bar  = 100 μm.</p

Topics: Cell Biology, Neuroscience, differentiation, ocular, adnexa
Year: 2013
DOI identifier: 10.1371/journal.pone.0047168.g007
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Provided by: FigShare
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