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Comparison of antibody responses against peptides with adjuvant vs. LCP-peptides alone.

By Mariusz Skwarczynski (140860), Annette M. Dougall (304395), Makan Khoshnejad (304396), Saranya Chandrudu (304397), Mark S. Pearson (304398), Alex Loukas (11035) and Istvan Toth (140874)

Abstract

<p>(a) LCP-2 (A<sub>291</sub>Y-GCN4-LCP) is more immunogenic than peptide 2 (A<sub>291</sub>Y-GCN4 without LCP) formulated with Freund’s adjuvants. Antibody responses are depicted as OD values at a serum dilution of 1∶100 where each serum was used to probe its cognate immunogen peptide or LCP. (b) Higher antibody titres were observed in mice immunised with 60 µg of <b>LCP-2</b> without Freund’s adjuvants (experiment 2). Total IgG binding to plated <b>LCP-2</b> from individual mice on day 42 serial dilution from 1∶100 to 1∶10000. Each symbol represents a single animal.</p

Topics: Biochemistry, Chemistry, Immunology, Infectious Diseases, antibody, responses, peptides, adjuvant, lcp-peptides
Year: 2013
DOI identifier: 10.1371/journal.pone.0046870.g004
OAI identifier: oai:figshare.com:article/235294
Provided by: FigShare
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