Effect of reference compounds on carrageenan induced monoarthritis.

Abstract

†<p>LoQ = limit of quantification.</p><p><b>Note:</b> Testing was performed 3 hours after carrageenan injection except for the naproxen experiment when testing took place 5 hours after carrageenan. Oxycodone was given subcutaneously 30 min before test while all other compounds were administered per os 4 hours before testing. Plasma samples were taken from satellite animals (n = 3 per group) at the time of testing or from the tested animals at termination of the experiment corresponding to about 5 hours 20 min after administration of naproxen, 3 hours after oxycodone and 7 hours after ibuprofen, diclofenac and paracetamol. Statistically different from vehicle group:</p>*<p> = <i>p</i><0.05,</p>**<p> = <i>p</i><0.01,</p>***<p> = <i>p</i><0.001, Dunnett's Multiple Comparison test subsequent to 1-way ANOVA.</p

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Last time updated on 16/03/2018

This paper was published in FigShare.

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