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Effect of LPA and COX inhibitors on the production of PGE2.

By Micaela S. Sordelli (304944), Jimena S. Beltrame (304945), Maximiliano Cella (304946), María Gracia Gervasi (304947), Silvina Perez Martinez (304948), Juliana Burdet (304949), Elsa Zotta (304950), Ana M. Franchi (284968) and María Laura Ribeiro (304951)


a<p>:p<0.001 vs the rest.</p><p>Uterine strips from rats pregnant on day 5 of gestation were incubated for 6 h with LPA 50 µM alone or in the presence of indomethacin 1 µM (a non selective COX-1 and COX-2 inhibitor) or NS-398 1 µM (a selective COX-2 inhibitor). In another set of experiments, the tissue was incubated for 6 h with indomethacin or NS-398 alone. The production of PGE2 was determined by radioimmunoassay.</p

Topics: Biochemistry, Cell Biology, Neuroscience, Immunology, Developmental Biology, lpa, cox, inhibitors
Year: 2013
DOI identifier: 10.1371/journal.pone.0046059.t004
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Provided by: FigShare
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