Effect of LPA and COX inhibitors on the production of PGE2.
a<p>:p<0.001 vs the rest.</p><p>Uterine strips from rats pregnant on day 5 of gestation were incubated for 6 h with LPA 50 µM alone or in the presence of indomethacin 1 µM (a non selective COX-1 and COX-2 inhibitor) or NS-398 1 µM (a selective COX-2 inhibitor). In another set of experiments, the tissue was incubated for 6 h with indomethacin or NS-398 alone. The production of PGE2 was determined by radioimmunoassay.</p
Biochemistry, Cell Biology, Neuroscience, Immunology, Developmental Biology, lpa, cox, inhibitors
DOI identifier: 10.1371/journal.pone.0046059.t004
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