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Effect of Netrin-1 on plasma cytokines level.

By Ji Chen (69329), Qing-ping Cai (305317), Pi-jie Shen (305320), Rong-lin Yan (305322), Chang-ming Wang (132074), De-jun Yang (305324), Hong-bing Fu (305326) and Xue-yun Chen (305328)


<p>IL-1β, IL-6, TNF-α, and IL-10 plasma concentrations at the indicated times are shown for the normal group and AP groups with and without netrin-1 treatment. Acute pancreatitis was induced by two intraperitoneal injections of L-Arginine (4 g/kg, 1 h apart). Mice were treated with recombinant mouse netrin-1 at a dose of 1 µg/mouse or vehicle (0.1% BSA) immediately after the second injection of L-Arginine and every 24 h thereafter. Data are presented as mean±SD (n = 6 per group in the normal mice, n = 8 per group both in the AP model and netrin-1 treated AP model). <sup>*</sup><i>P</i><0.05.</p

Topics: Chemistry, Immunology, netrin-1, plasma, cytokines
Year: 2013
DOI identifier: 10.1371/journal.pone.0046201.g004
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Provided by: FigShare
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