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IL-27-induced mRNA expression of gp130 is impaired in HIV infection.

By Christina Guzzo (305744), Wilma M. Hopman (305745), Nor Fazila Che Mat (305746), Wendy Wobeser (305747) and Katrina Gee (305748)

Abstract

<p>(A) Purified blood monocytes were stimulated with IL-27 for 4, 8, and 16 h, then analyzed by real-time PCR for mRNA expression of gp130 (n = 4). (B) Monocytes from HIV negative (n = 8) and HIV positive subjects (n = 7) were stimulated for 4 h with IL-27, and then analyzed by real-time PCR for gp130 mRNA expression. Comparison of gp130 expression between the two groups was performed with an independent samples t-test. Data shown have been normalized to 18SrRNA expression, and represent IL-27-mediated induction of gp130 expression relative to expression levels in unstimulated cells (Medium).</p

Topics: Immunology, Infectious Diseases, Virology, mrna, gp130, impaired, hiv
Year: 2013
DOI identifier: 10.1371/journal.pone.0045706.g002
OAI identifier: oai:figshare.com:article/240417
Provided by: FigShare
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