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IL-27-induced mRNA expression of gp130 is impaired in HIV infection.

By Christina Guzzo (305744), Wilma M. Hopman (305745), Nor Fazila Che Mat (305746), Wendy Wobeser (305747) and Katrina Gee (305748)


<p>(A) Purified blood monocytes were stimulated with IL-27 for 4, 8, and 16 h, then analyzed by real-time PCR for mRNA expression of gp130 (n = 4). (B) Monocytes from HIV negative (n = 8) and HIV positive subjects (n = 7) were stimulated for 4 h with IL-27, and then analyzed by real-time PCR for gp130 mRNA expression. Comparison of gp130 expression between the two groups was performed with an independent samples t-test. Data shown have been normalized to 18SrRNA expression, and represent IL-27-mediated induction of gp130 expression relative to expression levels in unstimulated cells (Medium).</p

Topics: Immunology, Infectious Diseases, Virology, mrna, gp130, impaired, hiv
Year: 2013
DOI identifier: 10.1371/journal.pone.0045706.g002
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Provided by: FigShare
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