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Synthetic E-peptide sequences.

By Becky K. Brisson (306176) and Elisabeth R. Barton (188414)


<p><b>A</b>. Rodent <i>Igf1</i> 3′ splicing leads to two mRNA isoforms. While mature IGF-I is encoded by exons 3 and 4, the E-peptides are encoded by exons 4, 5, and/or 6. EA isoforms exclude exon 5, while EB isoforms retain exon 5, leading to an altered reading frame and earlier stop codon in exon 6. Exons not drawn to scale <b>B</b>. Synthetic E-peptide amino acid sequences. EA and EB are less than 50% identical. Scr = Scrambled peptide. * = potential glycosylation sites in EA. The portion of EB that corresponds to MGF is <u>underlined</u>.</p

Topics: Biochemistry, Cell Biology, Physiology, e-peptide
Year: 2013
DOI identifier: 10.1371/journal.pone.0045588.g001
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Provided by: FigShare
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