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Distribution of <i>FMR1</i> genotypes and sub-genotypes in women with <i>BRCA1/2</i> mutations (black bars) and U.S. (gray) comparison group; * within each category denotes significance at P<0.05. Noteworthy are the excess of <i>het-norm/low</i> and complete absence of <i>het-norm/high</i> in <i>FMR1</i> sub-genotypes in <i>BRCA1/2</i> mutation carriers, and the very low prevalence of women with <i>norm FMR1</i> genotype.

By Andrea Weghofer (235033), Muy-Kheng Tea (308359), David H. Barad (235040), Ann Kim (308363), Christian F. Singer (308365), Klaus Wagner (198742) and Norbert Gleicher (235028)

Abstract

<p>A numerical presentation of these data is presented in (a), In description of genotypes <i>norm</i> stands for normal, <i>het</i> for heterozygous and <i>hom</i> for homozygous. In description of sub-genotypes <i>high</i> stands for CGG<sub> n>34</sub> and <i>low</i> for CGG<sub> n<26.</sub></p

Topics: Genetics, Biotechnology, Evolutionary Biology, Cancer, genotypes, sub-genotypes, women, mutations, denotes, noteworthy, excess, mutation, prevalence
Year: 2013
DOI identifier: 10.1371/journal.pone.0044753.g001
OAI identifier: oai:figshare.com:article/250114
Provided by: FigShare
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