Effects of nicorandil on body weight, right ventricle systolic pressures and hypertrophy in rats on weeks 1–3 after monocrotaline administration.

Abstract

<p>Measurements for the (A) BW, (B) RVSP, (C) RV/BW ratio, and (D) RV/(LV+S) ratio are presented as mean ± SD. BW, body weight; RVSP, right ventricle systolic pressures; MCT, monocrotaline. RV/BW represents the ratio of RV weight to BW, and RV/[LV+S] represents the ratio of the RV weight to left ventricular(LV) plus septum (S) weight. These are indicators of RV hypertrophy. Male SD rats were given a single dose (60 mg/kg) of MCT intraperitoneally and then fed 7.5 mg·kg<sup>−1</sup>·d<sup>−1</sup> nicorandil (nicorandil-treated group), 5 mg·kg<sup>−1</sup>·d<sup>−1</sup> 5-hydroxydecanoate (5-HD) combined with 7.5 mg·kg<sup>−1</sup>·d<sup>−1</sup> nicorandil (nicorandil+5-HD-treated group), or saline (MCT-treated group) by oral gavage from day 1 to day 21. The age- and weight-matched control animals were injected with an equal volume of saline (control group) intraperitoneally, and then given saline for 21 d. CON represents the control group, MCT represents the MCT-treated group, Nico represents the nicorandil-treated group, Nico+5-HD group represents the nicorandil+5-HD-treated group. n = 8 for each group except for n = 7 in Nico+5-HD group at the second week, n = 6 in MCT group and n = 5 in Nico+5-HD group at third week after MCT injection. *<i>P</i><0.05 compared with control group, #<i>P</i><0.05 relative to the MCT-treated group. +<i>P</i><0.05 relative to the nicorandil-treated group.</p

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Last time updated on 16/03/2018

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