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Type I collagen deposition surrounding <i>S. aureus</i> biofilms is enhanced following MyD88 loss.

By Mark L. Hanke (116810), Amanda Angle (312847) and Tammy Kielian (116814)

Abstract

<p>Biofilm-infected tissues were recovered from MyD88 knockout (KO) and wild type (WT) mice at the indicated time points following infection, whereupon sections were processed by immunofluorescence staining for type I collagen (red; A). Tissues were stained with DAPI (blue) to demarcate nuclei and asterisks denote the original location of infected catheters that were non-adherent to glass slides. (B) Quantitation of type I collagen fluorescence surrounding <i>S. aureus</i> biofilms of MyD88 KO and WT mice. Results are representative of tissues collected from five individual animals per group for each time point where significant differences are indicated with an asterisk (*<i>p</i><0.05).</p

Topics: Microbiology, Immunology, Infectious Diseases, collagen, deposition, biofilms, enhanced, myd88
Year: 2013
DOI identifier: 10.1371/journal.pone.0042476.g005
OAI identifier: oai:figshare.com:article/267985
Provided by: FigShare
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