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The Δ15N deletion abolished A3H HapII anti-viral activity and virion incorporation.

By Anjie Zhen (313428), Juan Du (118107), Xiaohong Zhou (62510), Yong Xiong (313431) and Xiao-Fang Yu (248189)


<p>To compare anti-viral activity and packaging of A3H HapII and HapIIΔ15N, pNL4–3Δvif was transfected with decreasing doses of A3H HapII and HapIIΔ15N. A) A3H HapIIΔ15N had no anti-viral activity compared to A3H HapII. B) Even when expressed at similar levels as A3H HapII (cell lysates in lane 3 and 5), A3H HapIIΔ15N completely lost its ability to be packaged into HIV-1.</p

Topics: Biochemistry, Genetics, Evolutionary Biology, Biological Sciences, Virology, deletion, abolished, a3h, hapii, anti-viral, virion
Year: 2013
DOI identifier: 10.1371/journal.pone.0038771.g006
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Provided by: FigShare
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