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The effect of SIP and fludarabine on leptin-induced Stat1 and Stat3 activation.

By Eduardo Martinez-Abundis (314136), Venkatesh Rajapurohitam (314137), James V. Haist (314138), Xiaohong T. Gan (314139) and Morris Karmazyn (314140)

Abstract

<p>Panels A and B show time-dependent leptin-induced increases in Stat1 phosphorylation in the absence or presence of the Stat inhibitory peptide (SIP), respectively. Panel C shows complete inhibition of leptin-induced Stat1 phosphorylation by fludarabine although the increased Stat3 phosphorylation was unaffected (panel D). As shown in the inset (panel E) fludarabine had no effect on leptin-induced mPTP opening. Values indicate mean + SEM, Nā€Š=ā€Š5. *P<0.05 from control (Ctl).</p

Topics: Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, sip, fludarabine, leptin-induced, stat1, stat3
Year: 2013
DOI identifier: 10.1371/journal.pone.0041612.g003
OAI identifier: oai:figshare.com:article/273366
Provided by: FigShare
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