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CDK1 activity is increased after spinal cord injury.

By Junfang Wu (242824), Giorgi Kharebava (314391), Chunshu Piao (314392), Bogdan A. Stoica (314393), Michael Dinizo (314394), Boris Sabirzhanov (314395), Marie Hanscom (314396), Kelsey Guanciale (314397) and Alan I. Faden (314398)

Abstract

<p>Western blotting analysis of common CDK substrates, CDK1 co-activator cyclin B1 and phosphorylations of specific CDK1 substrate (Ser54)-n-myc was performed in homogenates obtained from intact and injured spinal cord. <b>A</b>. Cyclin B1 expression was upregulated at all time points tested. Phosphorylation (Ser54) of n-myc and phospho-CDK substrate motif signal levels were increased from 5 h to day 7. <b>B–D</b>. Quantification of respective western blots in panel A. n = 4 rats/time point. *P<0.05 vs sham group.</p

Topics: Cell Biology, Neuroscience, spinal
Year: 2013
DOI identifier: 10.1371/journal.pone.0042129.g002
OAI identifier: oai:figshare.com:article/274121
Provided by: FigShare
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