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L-Arginine transport and extracellular adenosine concentration.

By Enrique Guzmán-Gutiérrez (295518), Francisco Westermeier (314855), Carlos Salomón (314856), Marcelo González (314858), Fabián Pardo (295519), Andrea Leiva (295520) and Luis Sobrevia (295521)

Abstract

<p>(a) Overall (300 µmol/L) L-arginine transport in HUVECs cultured (8 hours) in absence (white bars) or presence (black bars) of 1 nmol/L insulin, without (–NBTI) or with (+NBTI) 10 µmol/L nitrobenzylthioinosine (NBTI). Cells were co-incubated in culture medium without (–) or with (+) CGS-21680 (30 nmol/L) or ZM-21385 (10 nmol/L). (b) L-Arginine transport in the absence or presence of NECA (10 nmol/L) or DPCPX (10 nmol/L) in cells as in (a). (c) Adenosine concentration in the culture medium in cells as in (a). *<i>P</i><0.05 versus cells in the absence of NBTI, CGS-21680 and ZM-241385 (control). Values are mean ± SEM (n = 6–18).</p

Topics: Biophysics, Biochemistry, Molecular Biology, Physiology, Chemistry, extracellular, adenosine
Year: 2013
DOI identifier: 10.1371/journal.pone.0041705.g001
OAI identifier: oai:figshare.com:article/275343
Provided by: FigShare
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