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Combined effects of <i>DAT1</i> and <i>COMT</i> genotypes on early visual contingent negative variation (CNV).

By Stephan Bender (157984), Thomas Rellum (314981), Christine Freitag (314982), Franz Resch (157990), Marcella Rietschel (128064), Jens Treutlein (314986), Christine Jennen-Steinmetz (314989), Daniel Brandeis (153110), Tobias Banaschewski (314992) and Manfred Laucht (314999)


<p><b>Top:</b> The effect of the <i>COMT</i> genotype on the time course of the visual early CNV is shown separately for the homozygous 6R–10R <i>DAT1</i> haplotype and the <i>DAT1</i> haplotype with at least one non-6R–10R allele. The same conventions as for <a href="" target="_blank">Figure 1</a> apply. <b>Bottom:</b> Topography of the visual early CNV (600–900 ms after the cue ‘A’) – combined influences of <i>DAT1</i> and <i>COMT</i> genotypes. Note that there were nearly no changes in visual early CNV topography but especially in the presence of the homozygous 6R–10R <i>DAT1</i> haplotype, the Met/Met <i>COMT</i> genotype increased visual occipito-temporal early CNV amplitude.</p

Topics: Genetics, Neuroscience, Physiology, Mental Health, genotypes, contingent
Year: 2013
DOI identifier: 10.1371/journal.pone.0041552.g002
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Provided by: FigShare
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