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Flowchart of the parallel screening strategy.

By Kai-Cheng Hsu (177095), Hui-Chen Hung (380011), Jim-Tong Horng (380012), Ming-Yu Fang (380013), Chun-Yu Chang (380014), Ling-Ting Li (180995), I-Jung Chen (380015), Yun-Chu Chen (380016), Ding-Li Chou (380017), Chun-Wei Chang (380018), Hsing-Pang Hsieh (139595), Jinn-Moon Yang (19619) and John T.-A. Hsu (9436)


<p>(A) Parallel screening against WT and MDR NAs. Compounds of the compound library were docked into both NAs using GEMDOCK. (B) Characterization of the mutant subsite by site-moiety map analysis. In the NA site-moiety map, the hydrogen-bonding anchor (colored green) represents a polar environment interacting with polar moieties. (C) Selection of potential anti-resistance inhibitors. Compounds that simultaneously matched characteristics of the 5 subsites for the WT and MDR NAs were selected. (D) Bioassay for verifying the effects of selected compounds on WT and MDR NAs.</p

Topics: Biochemistry, Biotechnology, Biological Sciences, Infectious Diseases, Virology, parallel
Year: 2013
DOI identifier: 10.1371/journal.pone.0056704.g001
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Provided by: FigShare
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