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Concentration-dependence of the effect of BaCl<sub>2</sub> on AP amplitude and V<sub>max</sub>.

By Michael Xavier Doss (30403), José M. Di Diego (316836), Robert J. Goodrow (316837), Yuesheng Wu (316838), Jonathan M. Cordeiro (316839), Vladislav V. Nesterenko (316840), Héctor Barajas-Martínez (316841), Dan Hu (144171), Janire Urrutia (316842), Mayurika Desai (316843), Jacqueline A. Treat (316844), Agapios Sachinidis (30414) and Charles Antzelevitch (316845)

Abstract

<p>Concentration-dependence of the effect of BaCl<sub>2</sub> to reduce AP amplitude, V<sub>max</sub> and MDP in two population of beating clusters (BC). 100 µM BaCl<sub>2</sub> induced no changes in MDP in 13 out of 22 BC suggesting a small contribution or lack of I<sub>K1</sub> (<b>A, </b><b>C and E</b>), but led to membrane depolarization in 9 out of 22 BC (<b>B, D and F</b>). At concentrations at which BaCl<sub>2</sub> also blocks I<sub>Kr</sub> (500 µM), AP amplitude and V<sub>max</sub> decreased in both groups of BC. a: p<0.05 vs. Control; c: p<0.001 vs. Control.</p

Topics: Cell Biology, Physiology, Biotechnology, Immunology, Developmental Biology, ap, amplitude
Year: 2013
DOI identifier: 10.1371/journal.pone.0040288.g008
OAI identifier: oai:figshare.com:article/284707
Provided by: FigShare
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