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Effect of Ac-SDKP on expression of α-SMA and SRF in cultured rat fibroblasts.

By Hong Xu (71477), Fang Yang (123514), Ying Sun (23237), Yuan Yuan (25702), Hua Cheng (317084), Zhongqiu Wei (317086), Shuyu Li (18735), Tan Cheng (317088), Darrell Brann (317090) and Ruimin Wang (317092)


<p>TGF-β up-regulated the expression of α-SMA in fibroblasts to promote the differentiation from fibroblast to myofibroblast. In contrast, Ac-SDKP and LY364947 pretreatment prevented the α-SMA and SRF expression. A) α-SMA protein expression and distribution as analyzed by immunohistochemistry; B) Western blot analysis with antibodies against α-SMA and SRF; C) α-SMA protein expression measured by Western blot; D) SRF protein expression measured by Western blot; E) α-SMA mRNA expression measured by Real-time PCR; F) SRF mRNA expression measured by Real-time PCR.</p

Topics: Medicine, Molecular Biology, Physiology, Immunology, ac-sdkp, srf, cultured
Year: 2013
DOI identifier: 10.1371/journal.pone.0040301.g002
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Provided by: FigShare
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