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Clinically-relevant assessment for the development of experimental OM as determined by video otoscopy and tympanometry.

By M. Elizabeth Brockson (301571), Laura A. Novotny (317739), Joseph A. Jurcisek (317740), Glen McGillivary (240361), Martha R. Bowers (317741) and Lauren O. Bakaletz (240363)


<p>Expanded study: Intranasal challenge of chinchillas with NTHI, <i>M. catarrhalis</i> and RSV resulted in clinical indicators of otitis media as determined by otoscopy and tympanometry. (A) A healthy chinchilla tympanic membrane (TM), with both the annulum (a) and the umbo of the malleus (U) labeled. (B) Seven days after <i>M. catarrhalis</i> challenge, erythema (arrow) was observed along the umbo, along with darkening of the TM. Panels C-E – TM 11, 14 and 17 days after <i>M. catarrhalis</i> challenge, respectively, erythema (arrows) was observed along the annulum, over the U and across the TM (*).</p

Topics: Microbiology, Infectious Diseases, Virology, om, otoscopy
Year: 2013
DOI identifier: 10.1371/journal.pone.0040088.g005
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Provided by: FigShare
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