Clinically-relevant assessment for the development of experimental OM as determined by video otoscopy and tympanometry.

Abstract

<p>Expanded study: Intranasal challenge of chinchillas with NTHI, <i>M. catarrhalis</i> and RSV resulted in clinical indicators of otitis media as determined by otoscopy and tympanometry. (A) A healthy chinchilla tympanic membrane (TM), with both the annulum (a) and the umbo of the malleus (U) labeled. (B) Seven days after <i>M. catarrhalis</i> challenge, erythema (arrow) was observed along the umbo, along with darkening of the TM. Panels C-E – TM 11, 14 and 17 days after <i>M. catarrhalis</i> challenge, respectively, erythema (arrows) was observed along the annulum, over the U and across the TM (*).</p

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