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Bacterial burden in the lungs of mice.

By Ciaran Skerry (317997), Jamie Harper (317998), Mariah Klunk (317999), William R. Bishai (149943) and Sanjay K. Jain (318001)


<p>Six weeks after an aerosol infection with <i>Mycobacterium tuberculosis</i>, C3HeB/FeJ mice were split among four treatment groups: Untreated (no treatment), standard TB treatment (RHZ), etanercept alone and standard TB treatment with adjunctive etanercept (RHZ + Etanercept). The number of viable bacteria in the lungs were estimated by determining colony-forming units (CFU). Results are shown for the duration of study (panel A) and also as individual dot plots for 8 (panel B) and 10 (panel C) weeks after starting TB treatment. Compared to standard TB treatment, the addition of etanercept resulted in a significantly lower pulmonary bacterial burden, corresponding to the phase when a significant proportion of bacteria are multiplying slowly (panels B, C). Results are presented as mean (±SD) CFU in the lungs, detected from a minimum of four mice at each time point and for each group. CFU are presented on a logarithmic scale (log<sub>10</sub>) in panel A and on a linear scale for panels B and C and represent the same data.</p

Topics: Microbiology, Immunology, Infectious Diseases, lungs
Year: 2013
DOI identifier: 10.1371/journal.pone.0039680.g002
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Provided by: FigShare
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