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Supernatants of spheroid cells promote tube formation of EPCs through VEGF up-regulation.

By Bo Wei (188204), Xiao-Yan Han (318043), Cui-Ling Qi (318044), Shi Zhang (318045), Zong-Heng Zheng (318046), Yong Huang (15745), Tu-Feng Chen (318047) and Hong-Bo Wei (318048)

Abstract

<p>(A) Tube formation of EPCs treated by supernatants of spheroid cells was higher than their counterparts. And tube formation of EPCs was suppressed when we block the function of VEGF by bevacizumab. (B) The VEGF concentrations in supernatants of spheroid cells were higher than those of adherent cells. (C) Higher VEGF expression was observed in the spheroid cells compared with their counterparts.</p

Topics: Medicine, Cell Biology, Developmental Biology, Cancer, spheroid, cells, epcs, vegf
Year: 2013
DOI identifier: 10.1371/journal.pone.0039069.g006
OAI identifier: oai:figshare.com:article/288829
Provided by: FigShare
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