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TLR agonists induce production of high IL-1β, IL-6 and TNF-α levels by monocytes from <i>P. vivax</i>-infected subjects.

By Fabiana Maria de Souza Leoratti (318225), Silvia Cellone Trevelin (318226), Fernando Queiroz Cunha (318227), Bruno Coelho Rocha (318228), Pedro Augusto Carvalho Costa (133954), Humberto Doriguêtto Gravina (318230), Mauro Shugiro Tada (318232), Dhelio Batista Pereira (318235), Douglas Taylor Golenbock (318237), Lis Ribeiro do Valle Antonelli (318240) and Ricardo T. Gazzinelli (164680)


<p>Purified monocytes (A) or neutrophils (B) from <i>P. vivax-</i>infected subjects before (closed circles; n = 13) and 30–45 days after treatment (open circles; n = 13) were cultured for 48 hours in the absence or presence of LPS or Pam. Levels of IL-1β, IL-6, IL-10, TNF-α, and IL-8 (CXCL8) were measured in supernatant of monocyte (A) and neutrophil (B) cultures. Levels of cytokines were measured employing the Cytometric Bead Array (CBA). Significant differences are indicated <i>p</i>-values using paired t test or Wilcoxon signed rank test when a normality test failed.</p

Topics: Microbiology, Immunology, Infectious Diseases, agonists, induce, il-6, levels, monocytes
Year: 2013
DOI identifier: 10.1371/journal.pntd.0001710.g003
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Provided by: FigShare
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