Metabolites of curcuminoids in different cell lines.

Abstract

<p>(A) CCF-STTG1 cells were incubated with media containing 47 µM curcuminoids (SOLID+DMSO) for 24 h. During reversed phase chromatography of media samples, the elution profiles were monitored at wavelengths 280 nm (hatched lines), and 310 nm (solid lines). Prominent absorption peaks representing hexa- and octahydrocurcuminoids were detected at 280 nm wavelength. (B) Primarily hexahydrocurcuminoids were produced with similarly incubated HeLa cells, in addition to smaller amounts of curcuminoid reduction products C*, D*, and B*. (C). In contrast, NT2/D1 cells generated only reduction products C*, D*, and B*.</p

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