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Restoration of p53 function with CP-31398 sensitizes sarcoma cells to TNF-α-induced apoptosis.

By Jane Muret (318931), Meriem Hasmim (318932), Izabela Stasik (318934), Abdelali Jalil (318936), Aude Mallavialle (149715), Arash Nanbakhsh (318938), Ludovic Lacroix (235882), Katy Billot (318939), Véronique Baud (318941), Jérome Thiery (5652127), Philippe Vielh (318944), Philippe Terrier (304127), Joelle Wiels (5652130), Lyubomir Vassilev (318947), Axel Lecesne (318949), Sylvie Bonvalot (318952) and Salem Chouaib (213106)

Abstract

<p><i>A,</i> Western-blot analysis of p53 target gene expression in <i>TP53<sup>Mut</sup></i> cell lines (MFH100 and MFH152) after 24 h treatment with CP-31398. <i>B</i>, Apoptosis induction after 96 h of culture. Cells were treated either with CP-31398 alone (24 h), TNF-α alone (72 h) or both sequentially (24 h with CP followed by 72 h with TNF-α). Apoptosis was measured after 96 h by DiOC<sub>6</sub>/PI labeling; results from three independent experiments are shown. * p<0.05 versus CP-31398 or TNF-α treated cells.</p

Topics: Biochemistry, Cell Biology, Molecular Biology, Cancer, p53, cp-31398, sensitizes, sarcoma, cells
Year: 2013
DOI identifier: 10.1371/journal.pone.0038808.g004
OAI identifier: oai:figshare.com:article/292676
Provided by: FigShare
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