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Nefopam regulates scar size and β-catenin level in cutaneous wound repair.

By Raymond Poon (12265), Helen Hong (321136), Xin Wei (119082), James Pan (321137) and Benjamin A. Alman (205957)

Abstract

<p>A to D) Representative histologic sections through the widest margin of scars 14 days after wounding. A) A wound from a mouse treated with TGF-β. B) A wound in a mice treated with carrier only. C) A wound from a mouse treated with TGF-β and Nefopam. D) A wound from a mouse treated with Nefopam. Arrows show the widest width of the scar. The black line is 500 µm in length. E) A graphical representation of the mean and 95% confidence intervals of the widest diameter of the scars in µms. F) A representative Western blot mice showing the β-catenin protein levels in wounds from mice treated with TGF-β, Nefopam, or both, showing that Nefopam decreases β-catenin protein level in the wounds.</p

Topics: Molecular Biology, Ecology, Cancer, regulates, scar, cutaneous
Year: 2013
DOI identifier: 10.1371/journal.pone.0037940.g005
OAI identifier: oai:figshare.com:article/301943
Provided by: FigShare
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