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PMM resistance selection in promastigotes: <i>in vitro</i> PMM susceptibility (IC<sub>50</sub>) of <i>L. donovani</i> parasites cultured as promastigotes under increasing PMM drug pressure.

By Sarah Hendrickx (321143), Raquel Andrea Inocêncio da Luz (321144), Vasundhra Bhandari (162788), Kristel Kuypers (321145), Craig D. Shaw (321146), Julien Lonchamp (321147), Poonam Salotra (162805), Katharine Carter (321150), Shyam Sundar (58354), Suman Rijal (181185), Jean-Claude Dujardin (56958), Paul Cos (233137) and Louis Maes (191127)


<p>To determine amastigote susceptibility of the induced promastigotes, stationary-phase stages were used to infect mouse primary macrophages and J774 macrophages.</p><p> <i>P = parent non selected strain/R = selected resistant strain</i></p><p> <i>nd = not done.</i></p>*<p> <i>BPK087/0 cl-11: susceptible to Sb<sup>III</sup> (IC<sub>50</sub><15 µg/ml eq.) and resistant to Sb<sup>V</sup> (IC<sub>50</sub>>77 µg/ml eq.)</i></p

Topics: Infectious Diseases, pmm, susceptibility, parasites, cultured, promastigotes
Year: 2013
DOI identifier: 10.1371/journal.pntd.0001664.t001
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Provided by: FigShare
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