Article thumbnail

Effect of mAb dose and combination therapy in mice challenged with <i>B. pseudomallei</i> strain 1026b.

By David P. AuCoin (326003), Dana E. Reed (326004), Nicole L. Marlenee (179388), Richard A. Bowen (221292), Peter Thorkildson (326005), Barbara M. Judy (176551), Alfredo G. Torres (176570) and Thomas R. Kozel (326006)

Abstract

<p>Mice were administered mAb(s) by the i.p. route followed 18 h later by i.n. challenge with 15 LD<sub>50</sub> of <i>B. pseudomallei</i>. (A) Dose-response experiment in which mice were treated with the doses (µg) listed of each mAb alone. (B) Multiple doses of mAbs 3C5 and 4C7 were administered in combination at the doses (µg) listed. Mice were monitored for 42 days after which gross pathology and spleen cfu were determined on survivors (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035386#pone-0035386-t001" target="_blank">Table 1</a>). Control mice were not treated with mAb. <i>p</i> values of survival vs. controls are listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035386#pone-0035386-t001" target="_blank">Table 1</a>.</p

Topics: Microbiology, Immunology, Infectious Diseases, mab, mice, challenged
Year: 2013
DOI identifier: 10.1371/journal.pone.0035386.g002
OAI identifier: oai:figshare.com:article/322155
Provided by: FigShare
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://figshare.com/articles/... (external link)
  • http://www.plosone.org/article... (external link)
  • http://www.plosone.org/article... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.