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The top SNPs in each of the 9 sub-blocks in the <i>UGT1A</i> gene region (see Figure 2).

By Juulia Jylhävä (263169), Leo-Pekka Lyytikäinen (144253), Mika Kähönen (131499), Nina Hutri-Kähönen (186365), Johannes Kettunen (120333), Jorma Viikari (49741), Olli T. Raitakari (115559), Terho Lehtimäki (49739) and Mikko Hurme (240666)


<p>The four SNPs that are associated most significantly with serum cf-DNA levels are in sub-block 8.</p>†<p>For each SNP, the ancestral allele was modelled, and the β coefficient represents the change in cf-DNA level (µg/ml) with one additional copy of the ancestral allele.</p>*<p>Adjusted for age, sex, BMI and genetic East-West stratification in the Finnish population.</p><p>Abbreviations: SNP, single nucleotide polymorphism; Chr, chromosome; bp, base pairs; MAF, minor allele frequency; S.E., standard error.</p

Topics: Biophysics, Biochemistry, Physics, Cell Biology, Genetics, Molecular Biology, Biotechnology, snps, sub-blocks
Year: 2013
DOI identifier: 10.1371/journal.pone.0035426.t002
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Provided by: FigShare
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