TUNEL and H&E stained images of untreated, HerDox-treated, and Dox-treated tumors: (A) TUNEL images of untreated tumors (left), HerDox-treated tumors (middle) (injection drug dosage: 0.004 mg/kg×6 injections), Dox-treated tumors (right) (injection drug dosage: 0.04 mg/kg×6 injections) were acquired using confocal imaging (ex: 488 nm, em: 510–560 nm, and 10×) of tumor specimens.
<p>The arrows indicate the boundary between apoptotic and normal cells. Insets represent magnified images. (B) Average fluorescence of the TUNEL images of untreated, Dox-treated, HerDox-treated tumor sections (*: p<0.01) (C) H&E images of untreated (left), HerGa-treated tumors (middle), and Dox-treated tumors (right) were obtained using the Olympus microscope incorporating a CCD camera with a RGB filter (10×). The scale bar represents 200 µm. Arrows indicate nuclear shrinkage and fragmentation.</p
Cell Biology, Biotechnology, Cancer, stained, images, dox-treated, tunel, untreated, tumors, herdox-treated, acquired, confocal, imaging, 488
DOI identifier: 10.1371/journal.pone.0034463.g004
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