Electron micrographs of brain cells in uninjected and IT-injected (3 doses) I2S knockout mice.
<p>Pathological improvements occurred at the ultrastructural level. (<b>A</b>) Neurons of uninjected mice had lamellated inclusions, zebra body-like structures and vacuoles containing granular storage material (insert), which was reduced in I2S injected mice (<b>B</b>). Oligodendrocytes of uninjected mice showed large electron-lucent storage vacuoles (arrow; <b>C</b>) while oligodendrocytes of I2S-injected mice had minimal vacuolation (<b>D</b>).</p
Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, micrographs, cells, uninjected, it-injected, i2s, knockout
DOI identifier: 10.1371/journal.pone.0030341.g007
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