VU0183254 is an allosteric antagonist.

Abstract

<p><b>A.</b> Concentration response curves of AgOrco+AgOr65 expressing HEK cells in the presence of a series of steady concentrations (expressed as logM) of pre-loaded VU0183254 (different colored lines, see inset) followed by increasing concentrations of eugenol as measured using Fluo-4AM and an FDSS6000. <b>B.</b> As in A with VUAA1. <b>C.</b> As in A, with AgOrco+AgOr48 and delta-undecalactone. <b>D.</b> As in C with VUAA1. In all cases results are shown as means+/−SEM, n = 4.</p