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VU0183254 is an allosteric antagonist.

By Patrick L. Jones (192712), Gregory M. Pask (192710), Ian M. Romaine (335211), Robert W. Taylor (19686), Paul R. Reid (335216), Alex G. Waterson (335218), Gary A. Sulikowski (214879) and Laurence J. Zwiebel (140337)


<p><b>A.</b> Concentration response curves of AgOrco+AgOr65 expressing HEK cells in the presence of a series of steady concentrations (expressed as logM) of pre-loaded VU0183254 (different colored lines, see inset) followed by increasing concentrations of eugenol as measured using Fluo-4AM and an FDSS6000. <b>B.</b> As in A with VUAA1. <b>C.</b> As in A, with AgOrco+AgOr48 and delta-undecalactone. <b>D.</b> As in C with VUAA1. In all cases results are shown as means+/−SEM, n = 4.</p

Topics: Microbiology, Neuroscience, Chemistry, allosteric
Year: 2013
DOI identifier: 10.1371/journal.pone.0030304.g003
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Provided by: FigShare
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