Signal detection for statin-associated muscular adverse events.

Abstract

<p>N: the number of co-occurrences.</p><p>PRR: the proportional reporting ratio <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028124#pone.0028124-Evans1" target="_blank">[19]</a>, ROR: the reporting odds ratio <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028124#pone.0028124-vanPuijenbroek1" target="_blank">[20]</a>, IC: the information component <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028124#pone.0028124-Bate1" target="_blank">[21]</a>, EBGM: the empirical Bayes geometric mean <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028124#pone.0028124-Szarfman1" target="_blank">[22]</a>.</p><p>CI: the confidence interval; two-sided for ROR and IC, and one-sided for EBGM.</p><p>*: signal detected, see “<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028124#s2" target="_blank">Methods</a>” for the criteria of detection.</p><p>Myalgia, rhabdomyolysis and increase of creatine phosphokinase (CPK) level were coded as PT10028411, PT10039020 and PT10005470, respectively.</p

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