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Antibody response in hamsters immunized with recombinant LigA proteins or heat-killed leptospires (HKL).

By Mariana L. Coutinho (337710), Henry A. Choy (36168), Melissa M. Kelley (230543), James Matsunaga (230552), Jane T. Babbitt (230555), Michael S. Lewis (337711), Jose Antonio G. Aleixo (337712) and David A. Haake (36179)


<p>Total hamster immunoglobulin responses to immunogens were measured by ELISA. Geometric mean end-point titers and standard deviations (nā€Š=ā€Š4) are shown after the first (gray), second (blue), and third (black) immunizations. In all cases, pre-immune sera were negative. Recombinant LigA proteins are represented by their domain numbers. Asterisks indicate proteins that provided 100% protection against lethal challenge.</p

Topics: Microbiology, hamsters, immunized, recombinant, liga, proteins, heat-killed, leptospires
Year: 2013
DOI identifier: 10.1371/journal.pntd.0001422.g001
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Provided by: FigShare
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