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Effect of CBD in rectal biopsies of patients with ulcerative colitis (UC) in the remission phase.

By Daniele De Filippis (127374), Giuseppe Esposito (214517), Carla Cirillo (338171), Mariateresa Cipriano (124318), Benedicte Y. De Winter (283200), Caterina Scuderi (214518), Giovanni Sarnelli (338173), Rosario Cuomo (338175), Luca Steardo (214519), Joris G. De Man (338178) and Teresa Iuvone (127378)


<p>(A) shows the effect of CBD on glial activation evaluated as S100B protein expression. Western blot and relative densitometric analysis evidenced that CBD significantly and in a concentration dependent manner reduced LPS- induced S100B. (B) shows the effect of CBD on LPS + INF-γ induced iNOS protein expression and (C) nitrate production. <a href="" target="_blank">Results</a> are expressed as mean ± SEM of 3 experiments ***p<0.001 vs. CTR; °p<0.05, °°°p<0.001 vs. LPS+INF-γ.</p

Topics: Biochemistry, Microbiology, Neuroscience, Pharmacology, Biotechnology, Chemistry, Immunology, cbd, rectal, biopsies, patients, ulcerative, colitis, remission
Year: 2013
DOI identifier: 10.1371/journal.pone.0028159.g007
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Provided by: FigShare
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