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Antiviral agents reduce the HSV1-induced increases in tau-related enzymes.

By Matthew A. Wozniak (342329), Alison L. Frost (342331), Chris M. Preston (342333) and Ruth F. Itzhaki (342336)


<p>Vero cells were infected with HSV1 SC16 at an MOI of 1 for 16 hours. Cells were treated with 0 µM, 50 µM, 100 µM or 200 µM acyclovir (ACV), penciclovir (PCV) or foscarnet (FOS) which was present throughout infection. After fixation the slides were tested for (A) protein kinase A (PKA) and (B) glycogen synthase kinase 3β (GSK3β). Images for no antiviral, 50 µM ACV, 50 µM PCV and 100 µM FOS are shown. Scale bar: 50 µm.</p

Topics: Biochemistry, Neuroscience, Infectious Diseases, Virology, agents, hsv1-induced, increases, tau-related
Year: 2013
DOI identifier: 10.1371/journal.pone.0025152.g010
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Provided by: FigShare
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