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MIF increases morbidity and mortality during peroral <i>T. gondii</i> infection.

By Marta G. Cavalcanti (343508), Jacilene S. Mesquita (343509), Kalil Madi (329472), Daniel F. Feijó (343510), Iranaia Assunção-Miranda (343512), Heitor S. P. Souza (329477) and Marcelo T. Bozza (343514)

Abstract

<p>Survival curves of <i>Mif</i><sup>−</sup>/<sup>−</sup> (C57BL/6) mice (6–8 weeks old) and age and sex-matched wild type controls orally infected with 100 (A) and 20 cysts (B) of ME-49 strain of <i>T. gondii</i>. Morbidity was evaluated by determining animal (C) relative weight loss and (D) hematocrit. One representative experiment out of three performed. Data from 8 to 10 animals per group are given as mean ± SEM, and p values were determined by t-test (* p≤0.05) or by Log-rank test (A, B). Cont, control not infected.</p

Topics: Microbiology, Chemistry, Immunology, Infectious Diseases, increases, morbidity, peroral
Year: 2013
DOI identifier: 10.1371/journal.pone.0025259.g001
OAI identifier: oai:figshare.com:article/402455
Provided by: FigShare
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