<p>Histological examination was performed from resulting tumors in the cell mixing experiments (n = 3) to determine the fraction of stem-like cells as assessed by Sox2 expression and the presence of proliferating cells as confirmed by the M-phase marker phosphorylated histone 3 (PH3). Representative micrographs (<b>A</b>) and bar graph (<b>B</b>) demonstrate Sox2 expression (red) is associated with cancer stem cells and their descendants (green) but not with non-stem tumor cells and their descendants (blue). Representative micrographs (<b>C</b>) and bar graph (<b>D</b>) demonstrate PH3 expression (red) is associated with cancer stem cells and their descendants (green) but not with non-stem tumor cells and their descendants (blue). Scale bar represents 50 µm. Data displayed as mean values +/− S.E.M. ***, p<0.001 as assessed by one-way analysis of variance (ANOVA), nuclei counterstained with Draq5 (purple).</p
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